This may and is strange, but for me , I will eat a peanut butter sandwich and drink full a glass of water with 2 heeping spoons of local honey ( I buy it by the gallons) and fresh squeezed lemon and 2-4 taplespoons of apple cider vinegar . also good for many other things .
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This is completely unscientific… but my thoughts.
I notice with some of my home made vapes I end up getting indigestion; most notably when they are very fruity in taste… real mouthwatering vapes…
What I think is happening is that the taste receptors and spit production get kicked into gear which then means lots of swallowing of spit which then kicks of the digestive system (as well as being due to taste, it’s an autonomic response) as if your body was preparing to digest the food that… well never arrives.
Obviously with the increased production of bile in the stomach (I’m probably forgetting my high school biology here, but you get the idea), and the increased swallowing of spit, with no actual food the body ends up producing to much acid/bile/magic digestive stuff – hence acid reflux and general indigestion.
I find that just a normal cup of coffee tends to resolve the problem, or a couple of biscuits with a nice cup of Yorkshire tea.
As I say, anecdotal and not scientific… but based on a very loose idea of autonomic biology from school, most of which I’ve forgotten. 
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The only thing I notice is some minty vapes if I vape too much have a bit of a …how shall we say it… I guess there’s no nice way to say pro-biotic or laxative but it’s not severe or anything.
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Should we call this:
E-juice jogs?
Vaper’s-bung?
Vape-bowel?
Mixer’s mud-butt?
Im just spitballing here…
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All of the above!
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Sorry @SmilingOgre but I really had to laugh reading this. 
Was it intentional or a freudian slip? It’s hard to tell with an Ogre.
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Being in the medical field and having other vapors express their concerns over this very subject I did get some information about this sometime last year or so. Upon speaking to a gastroenterologist and reading the literature he pointed me to I found some answers as I too have had this problem on an empty stomach sometimes.
About all of the information led to the same result. Most stimulants will stimulate the secretion of gastric acid which may burden the stomach and cause abdominal distress, which makes you feel nausea and especially more so if it is empty. The stomach secretes the acid and there is nothing for it to work with. If your body is lacking water or you are dehydrated, it intensifies the effect.
I also have a theory as to what could possible be another trigger. Not only that nicotine being a stimulant but what is it that we are doing when vaping? We are vaping flavors and sweet tasting ones at that. What happens when we eat and taste sweet? Hormone response and digestive enzyme response right? We start digesting before we even swallow our food so it makes sense that vaping would start up a digestive response but guess what, no food is present to be digested. Now I would say that could be another piece of the puzzle but do not know to what extent or even if it does in fact cause an unwanted effect of nausea. I have not found a vaping study on this and this is strictly a theory and no claim of anything, just suspicion. Food for thought right?
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No need to apologize. Congratulations you are the first to catch that! Gotta be careful vaping on an empty stomach ya know.
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While I’ve experienced this as well when I vaped using nicotine. I’m not sure if it’s happened since backing off thou.
Yes all the hypothesizing on the vaping and tricking the body those all sort of make sense but mastication needs to take place for Amylase to secrete for digestion to take place in the mouth. But then again there are other secretions outside of Amylase.
Nicotine like what @Beaufort_Batches was discussing it relaxing stuff. Here’s a blurp from google
If you smoke or chew tobacco, stop. The nicotine from tobacco relaxes the valve between the esophagus and stomach (lower esophageal sphincter). This can allow stomach acid and juices, the chemicals that break down food in the stomach, to back up (reflux) into the esophagus, which causes heartburn.
So there’s another proposal the LES ( Lower esophageal sphincter ) becoming too relax allowing a flap so the acid can now travel up instead of headed in the opposite direction to digest your food.
Just curious if any non nicotine vapers are experiencing it ?
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BUMP
Anybody?
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I get bad heartburn vaping tobaccos.
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But do you use nicotine in your blends ? Since I’ve went nic free I don’t recall an episode.
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I nearly always use nicotine (unless it’s simple SFT), but I don’t always get heartburn. I’m vaping on a butter cookie now and I can just keep on vaping it without any issues. Especially with some fruits, acid build up starts from the first puff. It’s really weird.
For months I was vaping fruits in everything so I didn’t really take notice, but the last couple weeks I’ve been trying more cookies or simple vanilla creams without fruits and immediately noticed a difference.
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I had some problems after making my very first batch of DIY liquid about two weeks ago I think it was more the nicotine level and doing a shake a vape on it,even though its a single flavor candy cane mix it upset my stomach I made it at a 8mg strength which is only a small fraction up from 7.5 which is what I have been vaping by adding nicotine to my store bought stuff which was a 10% .
After a week of letting my DIY stuff sit empty stomach or full it has not given me any problems since,in fact I’m vaping it right now.
Kefir is good when made into a pineapple ice cream I also drink kombucha which almost instantly settles my stomach.
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@Amy2, yes, I aways spike everything with 3mg, but the only flavors that seem to do me in are tobacco flavors. 
That sux. Tobaccos for me are usually very smooth but then again I am not using any nicotine these days and I’ve most likely steeped it at least 1/2 a year lol not even kidding about that part 
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I vape 8mg nic I don’t get that
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Now you got me thinking…I have another problem I’ve noticed. Whenever I do a knuckle test of more than one flavor I get the hiccups. Yep every time! Anyone else have this too?
As far as stomach aches:
It could be from swallowing air or/and it could also possibly be the PG causing the esophageal splinter to tighten, when it comes into contact with it. That can cause stomach aches, flatulence, and possibly the hiccups and a few more things.
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Or nicups if your tester has nic in it - wayback when i thought nicotine mints were a good way to try and quit smoking I used to get them all the time. So bad they were the painful hiccups (nicotine induced hiccups are a thing)
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Oh interesting i wasn’t aware of that…nicups! I don’t know if it’s always from that because when i tested a bunch of testers with no Nic it happened too. I will make sure and pay special attn tho. I may have tested some with nic before the testers.
Ps
I have to go check into that now ty…thats the nurse in me. I love medical stuff
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