Team ELR has now broken our OWN record. About 7.5M per day !!!
As a reminder, it’s NEVER too late to join the team, and help out, and donate some free time from your computer.
Install Guides for Linux, Windows, and Mac:
https://foldingathome.org/support/faq/installation-guides/
Get Started, and download the FAH Client:
https://foldingathome.org/start-folding/
Make sure to Join Team: 261398
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Usually 30-40k of that is me (big ooh), but with temps in the 90s and the PC in a no-AC room, I’m having to shut things down during the hottest part of the day.
Every work unit counts @NoFumus, but you are right about the heat. Folding can make more of it LOL. We’re in the 80’s and 90’s, and I think I heard rumors of a “heat wave”, but hard to tell, as everything is being hyped these days.
Yet ANOTHER huge victory for Team ELR. Broke through the rank 900 barrier !!
| Date of last work unit | 2020-07-08 21:36:52 |
|---|---|
| Active CPUs within 50 days | 22 |
| Team Id | 261398 |
| Grand Score | 386,220,755 |
| Work Unit Count | 9,261 |
| Team Ranking | 895 of 254263 |
| Homepage | You too can help find a cure/treatment for Coronavirus |
| Fast Teampage URL | https://apps.foldingathome.org/teamstats/team261398.html |
Uhh Ohhhh…
09:19:28:WU02:FS01:0x22:Completed 280000 out of 1000000 steps (28%)
09:21:01:WU02:FS01:0x22:Completed 290000 out of 1000000 steps (29%)
09:22:37:WU02:FS01:0x22:Completed 300000 out of 1000000 steps (30%)
09:24:19:WU02:FS01:0x22:Completed 310000 out of 1000000 steps (31%)
09:25:55:WU02:FS01:0x22:Completed 320000 out of 1000000 steps (32%)
09:27:34:WU02:FS01:0x22:Completed 330000 out of 1000000 steps (33%)
09:28:38:WU02:FS01:0x22:An exception occurred at step 335586: Particle coordinate is nan
09:28:38:WU02:FS01:0x22:ERROR:98: Attempting to restart from last good checkpoint by restarting core.
09:28:38:WU02:FS01:0x22:Folding@home Core Shutdown: CORE_RESTART
09:28:39:WARNING:WU02:FS01:FahCore returned: CORE_RESTART (98 = 0x62)
09:28:39:WU02:FS01:Starting
09:28:39:WU02:FS01:Running FahCore: “C:\Program Files (x86)\FAHClient/FAHCoreWrapper.exe” C:\Users\SessionDrummer\AppData\Roaming\FAHClient\cores/cores.foldingathome.org/v7/win/64bit/Core_22.fah/FahCore_22.exe -dir 02 -suffix 01 -version 706 -lifeline 13036 -checkpoint 29 -gpu-vendor nvidia -opencl-platform 0 -opencl-device 0 -cuda-device 0 -gpu 0
09:28:39:WU02:FS01:Started FahCore on PID 11048
09:28:39:WU02:FS01:Core PID:5392
09:28:39:WU02:FS01:FahCore 0x22 started
09:28:39:WU02:FS01:0x22:*********************** Log Started 2020-07-09T09:28:39Z ***********************
09:28:39:WU02:FS01:0x22:*************************** Core22 Folding@home Core ***************************
Have a few of those 
16:38:52:WU01:FS01:0x22:An exception occurred at step 4266: Particle coordinate is nan
16:38:52:WU01:FS01:0x22:ERROR:98: Attempting to restart from last good checkpoint by restarting core.
16:38:52:WU01:FS01:0x22:Folding@home Core Shutdown: CORE_RESTART
16:38:52:WARNING:WU01:FS01:FahCore returned: CORE_RESTART (98 = 0x62)
06:33:34:WU00:FS01:0x22:Completed 290000 out of 1000000 steps (29%)
06:35:07:WU00:FS01:0x22:An exception occurred at step 296932: Particle coordinate is nan
06:35:07:WU00:FS01:0x22:ERROR:98: Attempting to restart from last good checkpoint by restarting core.
06:35:07:WU00:FS01:0x22:Folding@home Core Shutdown: CORE_RESTART
06:35:08:WARNING:WU00:FS01:FahCore returned: CORE_RESTART (98 = 0x62)
08:55:02:WU00:FS01:0x22:Completed 930000 out of 1000000 steps (93%)
08:55:32:WU00:FS01:0x22:An exception occurred at step 931209: Particle coordinate is nan
08:55:32:WU00:FS01:0x22:ERROR:98: Attempting to restart from last good checkpoint by restarting core.
08:55:32:WU00:FS01:0x22:Folding@home Core Shutdown: CORE_RESTART
08:55:32:WARNING:WU00:FS01:FahCore returned: CORE_RESTART (98 = 0x62)
09:06:27:WU00:FS01:0x22:Completed 950000 out of 1000000 steps (95%)
09:06:56:WU00:FS01:0x22:An exception occurred at step 951540: Particle coordinate is nan
09:06:56:WU00:FS01:0x22:ERROR:98: Attempting to restart from last good checkpoint by restarting core.
09:06:56:WU00:FS01:0x22:Folding@home Core Shutdown: CORE_RESTART
09:06:56:WARNING:WU00:FS01:FahCore returned: CORE_RESTART (98 = 0x62)
It does continue with the WU after restart …
Don’t think I’ve ever had a core restart before.
Not sure it’s the work units - it might be the algorithm or some calculation that fails for some reason - the error being “particle coordinate is nan” (not-a-number) 
Well @daath (and ELR Team), it appears they sorted out those bad work units, but looking like we ran outta work units all together again. I noticed the office wasn’t “warm” LOL, and …
21:32:02:WU02:FS01:Final credit estimate, 336705.00 points
21:32:02:WU02:FS01:Cleaning up
21:32:26:WU01:FS01:Connecting to assign1.foldingathome.org:80
21:32:26:WARNING:WU01:FS01:Failed to get assignment from 'assign1.foldingathome.org:80': No WUs available for this configuration
21:32:26:WU01:FS01:Connecting to assign2.foldingathome.org:80
21:32:26:WU01:FS01:Assigned to work server 3.133.76.19
21:32:26:WU01:FS01:Requesting new work unit for slot 01: READY gpu:0:TU102 [GeForce RTX 2080 Ti Rev. A] M 13448 from 3.133.76.19
21:32:26:WU01:FS01:Connecting to 3.133.76.19:8080
21:32:27:ERROR:WU01:FS01:Exception: Server did not assign work unit
21:35:03:WU01:FS01:Connecting to assign1.foldingathome.org:80
21:35:04:WARNING:WU01:FS01:Failed to get assignment from 'assign1.foldingathome.org:80': No WUs available for this configuration
21:35:04:WU01:FS01:Connecting to assign2.foldingathome.org:80
21:35:04:WARNING:WU01:FS01:Failed to get assignment from 'assign2.foldingathome.org:80': No WUs available for this configuration
21:35:04:WU01:FS01:Connecting to assign3.foldingathome.org:80
21:35:04:WARNING:WU01:FS01:Failed to get assignment from 'assign3.foldingathome.org:80': No WUs available for this configuration
21:35:04:WU01:FS01:Connecting to assign4.foldingathome.org:80
21:35:04:WARNING:WU01:FS01:Failed to get assignment from 'assign4.foldingathome.org:80': No WUs available for this configuration
21:35:04:ERROR:WU01:FS01:Exception: Could not get an assignment
21:39:18:WU01:FS01:Connecting to assign1.foldingathome.org:80
21:39:18:WU01:FS01:Assigned to work server 3.133.76.19
21:39:18:WU01:FS01:Requesting new work unit for slot 01: READY gpu:0:TU102 [GeForce RTX 2080 Ti Rev. A] M 13448 from 3.133.76.19
21:39:18:WU01:FS01:Connecting to 3.133.76.19:8080
21:39:18:ERROR:WU01:FS01:Exception: Server did not assign work unit
21:46:09:WU01:FS01:Connecting to assign1.foldingathome.org:80
21:46:09:WARNING:WU01:FS01:Failed to get assignment from 'assign1.foldingathome.org:80': No WUs available for this configuration
21:46:09:WU01:FS01:Connecting to assign2.foldingathome.org:80
21:46:09:WU01:FS01:Assigned to work server 3.133.76.19
21:46:09:WU01:FS01:Requesting new work unit for slot 01: READY gpu:0:TU102 [GeForce RTX 2080 Ti Rev. A] M 13448 from 3.133.76.19
21:46:09:WU01:FS01:Connecting to 3.133.76.19:8080
21:46:09:ERROR:WU01:FS01:Exception: Server did not assign work unit
21:57:15:WU01:FS01:Connecting to assign1.foldingathome.org:80
21:57:15:WU01:FS01:Assigned to work server 140.163.4.231
21:57:15:WU01:FS01:Requesting new work unit for slot 01: READY gpu:0:TU102 [GeForce RTX 2080 Ti Rev. A] M 13448 from 140.163.4.231
21:57:15:WU01:FS01:Connecting to 140.163.4.231:8080
21:58:02:ERROR:WU01:FS01:Exception: Server did not assign work unit
22:15:11:WU01:FS01:Connecting to assign1.foldingathome.org:80
22:15:11:WU01:FS01:Assigned to work server 3.133.76.19
22:15:11:WU01:FS01:Requesting new work unit for slot 01: READY gpu:0:TU102 [GeForce RTX 2080 Ti Rev. A] M 13448 from 3.133.76.19
22:15:11:WU01:FS01:Connecting to 3.133.76.19:8080
22:15:12:ERROR:WU01:FS01:Exception: Server did not assign work unit
22:20:17:WU01:FS01:Connecting to assign1.foldingathome.org:80
22:20:17:WARNING:WU01:FS01:Failed to get assignment from 'assign1.foldingathome.org:80': No WUs available for this configuration
22:20:17:WU01:FS01:Connecting to assign2.foldingathome.org:80
22:20:17:WU01:FS01:Assigned to work server 3.133.76.19
22:20:17:WU01:FS01:Requesting new work unit for slot 01: READY gpu:0:TU102 [GeForce RTX 2080 Ti Rev. A] M 13448 from 3.133.76.19
22:20:17:WU01:FS01:Connecting to 3.133.76.19:8080
22:20:17:ERROR:WU01:FS01:Exception: Server did not assign work unit
22:21:54:WU01:FS01:Connecting to assign1.foldingathome.org:80
22:21:54:WARNING:WU01:FS01:Failed to get assignment from 'assign1.foldingathome.org:80': No WUs available for this configuration
22:21:54:WU01:FS01:Connecting to assign2.foldingathome.org:80
22:21:54:WU01:FS01:Assigned to work server 3.133.76.19
22:21:54:WU01:FS01:Requesting new work unit for slot 01: READY gpu:0:TU102 [GeForce RTX 2080 Ti Rev. A] M 13448 from 3.133.76.19
22:21:54:WU01:FS01:Connecting to 3.133.76.19:8080
22:21:54:ERROR:WU01:FS01:Exception: Server did not assign work unitMaybe we should recharge the Flux Capacitor a bit ?
Top off Mr. Fusion ?
22:32:39:WU01:FS01:0x22:********************************************************************************
22:32:39:WU01:FS01:0x22:Project: 14468 (Run 0, Clone 1889, Gen 26)
22:32:39:WU01:FS01:0x22:Unit: 0x0000003303854c135eb98530b0a310cf
22:32:39:WU01:FS01:0x22:Reading tar file core.xml
22:32:39:WU01:FS01:0x22:Reading tar file integrator.xml
22:32:39:WU01:FS01:0x22:Reading tar file state.xml
22:32:39:WU01:FS01:0x22:Reading tar file system.xml
22:32:39:WU01:FS01:0x22:Digital signatures verified
22:32:39:WU01:FS01:0x22:Folding@home GPU Core22 Folding@home Core
22:32:39:WU01:FS01:0x22:Version 0.0.11
22:32:39:WU01:FS01:0x22: Checkpoint write interval: 100000 steps (5%) [20 total]
22:32:39:WU01:FS01:0x22: JSON viewer frame write interval: 20000 steps (1%) [100 total]
22:32:39:WU01:FS01:0x22: XTC frame write interval: 20000 steps (1%) [100 total]
22:32:39:WU01:FS01:0x22: Global context and integrator variables write interval: disabled
22:32:50:WU01:FS01:0x22:Completed 0 out of 2000000 steps (0%)
22:34:08:WU01:FS01:0x22:Completed 20000 out of 2000000 steps (1%)
22:35:26:WU01:FS01:0x22:Completed 40000 out of 2000000 steps (2%)
And now under 800! 
@28If, wow, that is very impressive news …
One million volunteers and more than 2.5 exaFLOPS later, the group behind the crowdsourced distributed-computing project says it has found possible targets for stopping the SARS-CoV-2 virus.
In its SARS-CoV-2 simulations, F@h first targeted the spike, the cone-shaped appendages on the surface of the virus consisting of three proteins. The spike must open to attach itself to a human cell to infiltrate and replicate. F@h’s mission was to simulate this opening process to gain unique insight into what the open state looks like and find a way to inhibit the connection between the spike and human cells.
And it did so. In a newly published paper, the Folding@home team said it was able to simulate an “unprecedented” 0.1 seconds of the viral proteome. They captured dramatic opening of the spike complex, as well as shape-shifting in other proteins that revealed more than 50 “cryptic” pockets that expand targeting options for the design of antivirals.
Abstract
SARS-CoV-2 has intricate mechanisms for initiating infection, immune evasion/suppression, and replication, which depend on the structure and dynamics of its constituent proteins. Many protein structures have been solved, but far less is known about their relevant conformational changes. To address this challenge, over a million citizen scientists banded together through the Folding@home distributed computing project to create the first exascale computer and simulate an unprecedented 0.1 seconds of the viral proteome. Our simulations capture dramatic opening of the apo Spike complex, far beyond that seen experimentally, which explains and successfully predicts the existence of “cryptic” epitopes. Different Spike homologues modulate the probabilities of open versus closed structures, balancing receptor binding and immune evasion. We also observe dramatic conformational changes across the proteome, which reveal over 50 “cryptic” pockets that expand targeting options for the design of antivirals. All data and models are freely available online, providing a quantitative structural atlas.
