It took forever to get through every post in this thread… But IIRC, I can’t believe no one mentioned Eureka! I loved that show, and hated that it got canceled. So many great ideas for crazy twists, and such an excellent cast! (Was even more upset when Netflix removed the first couple seasons, as I love to go back and rewatch things from time to time.)
It’s up there with Firefly in originality in my opinion!